May 2, 2026, 6:00AM - 1:00PM

777 Main Street, Cape Girardeau, MO 63701, USA

Whether you’re a regular participant, or looking to join your first ever Run, you’ve come to the right place. Muddy River Marathon is an engaging and fun event, geared towards people of all ages and from all walks of life.

The Muddy River Marathon offers two race formats – half marathon and half marathon relay. Our 13.1 mile and half marathon relay courses wind through Cape Girardeau, Missouri.

We believe that fitness equals happiness, and encourage our participants to challenge their bodies while maintaining a healthy lifestyle.

Ready for 2026

In 2026, participants should expect a great course, excellent post-race festivities and unmatched participant swag. We look forward to each racer and volunteer honoring the uniqueness of our hometown of Cape Girardeau and its famous river.

Join Us